YY/T 0688.1-2008 (English Version) PDF

Scope: This part of YY/T 0688 introduces a reference method for determining the MIC value of antibacterial agents—the broth microdilution method. The MIC value only reflects the antibacterial activity of the antibacterial agent under specified in vitro test conditions. When formulating a medication plan, doctors should not only refer to the MIC results, but also consider other factors such as the pharmacokinetics/pharmacodynamic parameters of the drug in the human body and the resistance mechanism of bacteria to antibacterial agents. For a certain antibacterial agent, the corresponding test bacteria can be divided into "sensitive (S)", "intermediary I)" and "resistant (R)" based on the in vitro susceptibility test results (MIC value). Additionally, the MIC value can be used to determine whether the test strain is wild type or non-wild type. Although interpreting the clinical significance of MIC values is beyond the scope of this section, in order to adapt to clinical needs, it is necessary to adapt the basic content of the method to different antimicrobial agent-bacteria combinations. These adjustments are reflected in the tables below. In order to ensure the comparability and reliability of test results, other drug susceptibility testing methods (such as conventional methods or antimicrobial susceptibility testing equipment) should be compared with this reference method to determine its accuracy.

YY/T 0688.1-2008 history

2023 YY/T 0688.1-2023 Performance evaluation of infectious pathogen susceptibility testing and antimicrobial susceptibility testing equipment Part 1: Broth microdilution reference method for the detection of in vitro activity of antimicrobial agents against fast-growing aerobi
2008 YY/T 0688.1-2008 Clinical laboratory testing and in vitro diagnostic test systems -Susceptibility testing of infectious agents and evaluation of performance of antimicrobial susceptibility devices -Part 1: Reference method for testing the in vitro activity of antimicrobia