YY/T 0688.1-2023 (English Version) PDF

Scope: This document describes a reference method for determining the MIC values of antimicrobial drugs, the broth microdilution method. The MIC value serves as a guide to physicians and reflects the antibacterial activity of an antimicrobial drug under specified in vitro test conditions, taking into account other factors such as drug pharmacology, pharmacokinetics, or bacterial resistance mechanisms. This allows bacteria to be classified as "susceptible (S)", "intermediate (I)" or "resistant (R)". Additionally, the distribution of MIC values can be used to determine wild-type or non-wild-type bacterial communities. Although clinical interpretation of MIC values is beyond the scope of this document, adjustments to some basic methods of antimicrobial-bacterial combinations are necessary to facilitate clinical interpretation. These adjustments are included in a separate appendix to this document. In order to ensure the comparability and reliability of test results, other drug susceptibility test methods (such as disk diffusion method or diagnostic test equipment) must be compared with this reference method for confirmation. This document applies to the determination of MIC values using the broth microdilution method.

YY/T 0688.1-2023 history

2023 YY/T 0688.1-2023 Performance evaluation of infectious pathogen susceptibility testing and antimicrobial susceptibility testing equipment Part 1: Broth microdilution reference method for the detection of in vitro activity of antimicrobial agents against fast-growing aerobi
2008 YY/T 0688.1-2008 Clinical laboratory testing and in vitro diagnostic test systems -Susceptibility testing of infectious agents and evaluation of performance of antimicrobial susceptibility devices -Part 1: Reference method for testing the in vitro activity of antimicrobia