ASTM F719-81(2007)e1
Standard Practice for Testing Biomaterials in Rabbits for Primary Skin Irritation

Standard No.

ASTM F719-81(2007)e1

Release Date

1981

Published By

American Society for Testing and Materials (ASTM)

Status

Be replaced

Replace By

ASTM F719-81(2012)

Latest

ASTM F719-20e1

Scope

Materials that are to be in contact with the skin should not cause irritation to the skin. Since it is probably the substances leached from a material that cause the irritation, this practice provides for direct material-skin contact testing or for skin exposure to the liquid extract of the test material. The rationale for this rabbit test is that it is a comparatively quick and inexpensive method which, through use over the years, has become a generally accepted method.

1.1 This practice covers a procedure by which the irritancy of a biomaterial may be assessed through contact with abraded and intact skin of rabbits.

1.2 The results of this practice depend upon the effectiveness with which contact between the skin and the test material is established and maintained. Because of the operator technique included in performing this test, it is important that the test be performed by personnel with appropriate training.

This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

ASTM F719-81(2007)e1 Referenced Document

• ASTM F619 Standard Practice for Extraction of Medical Plastics

ASTM F719-81(2007)e1 history

• 2020 ASTM F719-20e1 Standard Practice for Testing Materials in Rabbits for Primary Skin Irritation
• 2020 ASTM F719-20 Standard Practice for Testing Materials in Rabbits for Primary Skin Irritation
• 1981 ASTM F719-81(2012) Standard Practice for Testing Biomaterials in Rabbits for Primary Skin Irritation
• 1981 ASTM F719-81(2007)e1 Standard Practice for Testing Biomaterials in Rabbits for Primary Skin Irritation
• 1981 ASTM F719-81(2007) Standard Practice for Testing Biomaterials in Rabbits for Primary Skin Irritation
• 1981 ASTM F719-81(2002)e1 Standard Practice for Testing Biomaterials in Rabbits for Primary Skin Irritation
• 1981 ASTM F719-81(2002) Standard Practice for Testing Biomaterials in Rabbits for Primary Skin Irritation
• 1981 ASTM F719-81(1996)e1 Standard Practice for Testing Biomaterials in Rabbits for Primary Skin Irritation