5.1 Protection of a species requires prevention of unacceptable effects on the number, weight, health, and uses of the individuals of that species. A life-cycle toxicity test is conducted to determine what changes in the numbers and weights of individuals of the test species result from effects of the test material on survival, growth, and reproduction. Information might also be obtained on effects of the material on the health and uses of the species.
5.2 Results of life-cycle tests with mysids might be used to predict long-term effects likely to occur on mysids in field situations as a result of exposure under comparable conditions.
5.3 Results of life-cycle tests with mysids might be used to compare the chronic sensitivities of different species and the chronic toxicities of different materials, and also to study the effects of various environmental factors on results of such tests.
5.4 Results of life-cycle tests with mysids might be an important consideration when assessing the hazards of materials to aquatic organisms (see Guide E1023) or when deriving water quality criteria for aquatic organisms (1).4
5.5 Results of a life-cycle test with mysids might be useful for predicting the results of chronic tests on the same test material with the same species in another water or with another species in the same or a different water (2). Most such predictions take into account results of acute toxicity tests, and so the usefulness of the results from a life-cycle test with mysids is greatly increased by also reporting the results of an acute toxicity test (see Guide E729) conducted under the same conditions.
5.6 Results of life-cycle tests with mysids might be useful for studying the biological availability of, and structure-activity relationships between, test materials.
5.7 Results of life-cycle tests with mysids might be useful for predicting population effects on the same species in another water or with another species in the same or a different water (3).
1.1 This guide describes procedures for obtaining laboratory data concerning the adverse effects of a test material added to dilution water, but not to food, on certain species of saltwater mysids during continuous exposure from immediately after birth until after the beginning of reproduction using the flow-through technique. These procedures will probably be useful for conducting life-cycle toxicity tests with other species of mysids, although modifications might be necessary.
1.2 Other modifications of these procedures might be justified by special needs or circumstances. Although using appropriate procedures is more impo......
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