ASTM E1147-92(2005)
Standard Test Method for Partition Coefficient (N-Octanol/Water) Estimation by Liquid Chromatography

Standard No.

ASTM E1147-92(2005)

Release Date

1992

Published By

American Society for Testing and Materials (ASTM)

Status

Withdraw 2013-03

Latest

ASTM E1147-92(2005)

Scope

1.1 This test method describes a procedure for the estimation of the log of the octanol/water partition coefficient (log Kow) of chemicals over the range from 0 to 8.

1.2 This test method uses an empirically derived equation to relate the octanol/water partition coefficient to an experimentally determined retention time on a liquid chromatographic column.

1.3 This test method has been designed to estimate log Kow values for both non-ionizable and ionizable compounds. This is accomplished by buffering the liquid chromatographic solvent at a pH that will force the test compound into either the non-ionized or ionized form.

1.4 This test method requires some knowledge of the detector response to the chemical being tested.

1.5 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish safety and health practices and determine the applicability of regulatory limitations prior to use.

ASTM E1147-92(2005) Referenced Document

• ASTM D1193 Standard Specification for Reagent Water*， 1999-04-19 Update
• ASTM E1022 Standard Guide for Conducting Bioconcentration Tests with Fishes and Saltwater Bivalve Mollusks*， 1994-04-19 Update
• ASTM E200 Standard Practice for Preparation, Standardization, and Storage of Standard and Reagent Solutions for Chemical Analysis*， 1997-04-19 Update
• ASTM E682 Standard Practice for Liquid Chromatography Terms and Relationships*， 2019-09-01 Update

ASTM E1147-92(2005) history

• 1992 ASTM E1147-92(2005) Standard Test Method for Partition Coefficient (N-Octanol/Water) Estimation by Liquid Chromatography
• 1992 ASTM E1147-92(1997) Standard Test Method for Partition Coefficient (N-Octanol/Water) Estimation by Liquid Chromatography