ASTM G121-18
Standard Practice for Preparation of Contaminated Test Coupons for the Evaluation of Cleaning Agents

Standard No.

ASTM G121-18

Release Date

2018

Published By

American Society for Testing and Materials (ASTM)

Latest

ASTM G121-18

Scope

1.1 This practice describes the procedure for the preparation of singleand double-sided contaminated test coupons for the evaluation of cleaning agents. It is applicable for the evaluation of cleaning agents proposed for the cleaning of oxygen equipment, pharmaceutical manufacturing equipment, and medical devices (see Test Method G122 and Guide G127). It also is applicable to other systems where contamination is a concern. 1.2 Several classes of contaminants/residues most likely to be found in oxygen equipment, pharmaceutical manufacturing equipment, and medical devices are identified. However, if the user of this practice has identified contaminants not included in these classes, such identified contaminants may be substituted for the preparation of the test coupons if appropriate for this test method. 1.3 Solvent and cleaning agent compatibility with nonmetallic substrates should be verified prior to the preparation of the test coupons. Typical nonmetallic materials utilized in oxygen systems are contained in Guide G63. 1.4 This practice may involve hazardous materials, operations, and equipment. This practice does not purport to address all of the safety concerns associated with its use. It is the responsibility of whomever uses this practice to consult and establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use. 1.5 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.

ASTM G121-18 Referenced Document

• ASTM D1193 Standard Specification for Reagent Water
• ASTM E1235 Standard Test Method for Gravimetric Determination of Nonvolatile Residue (NVR) in Environmentally Controlled Areas for Spacecraft
• ASTM E3106 Standard Guide for Science-Based and Risk-Based Cleaning Process Development and Validation*， 2022-11-01 Update
• ASTM F303 Standard Practices for Sampling Aerospace Fluids from Components
• ASTM F312 Standard Test Methods for Microscopical Sizing and Counting Particles from Aerospace Fluids on Membrane Filters
• ASTM F3127 Standard Guide for Validating Cleaning Processes Used During the Manufacture of Medical Devices*， 2022-10-01 Update
• ASTM F324 
• ASTM F331 Standard Test Method for Nonvolatile Residue of Solvent Extract from Aerospace Components (Using Flash Evaporator)*， 2020-04-01 Update
• ASTM G122 Standard Test Method for Evaluating the Effectiveness of Cleaning Agents
• ASTM G127 Standard Guide for the Selection of Cleaning Agents for Oxygen Systems
• ASTM G63 Standard Guide for Evaluating Nonmetallic Materials for Oxygen Service
• ASTM G94 Standard Guide for Evaluating Metals for Oxygen Service

ASTM G121-18 history

• 2018 ASTM G121-18 Standard Practice for Preparation of Contaminated Test Coupons for the Evaluation of Cleaning Agents
• 1998 ASTM G121-98(2015)e1 Standard Practice for Preparation of Contaminated Test Coupons for the Evaluation of Cleaning Agents
• 1998 ASTM G121-98(2010)e1 Standard Practice for Preparation of Contaminated Test Coupons for the Evaluation of Cleaning Agents
• 1998 ASTM G121-98(2004) Standard Practice for Preparation of Contaminated Test Coupons for the Evaluation of Cleaning Agents
• 1998 ASTM G121-98 Standard Practice for Preparation of Contaminated Test Coupons for the Evaluation of Cleaning Agents