ABSTRACT The test material@ API #78-4@ #2 Home Heating Oil (50% Cat)@ was tested for potential acute toxicity@ using a battery of six tests: Primary Skin Irritation@ Primary Eye Irritation@ Skin Sensitization@ Acute Dermal Toxicity@ Acute Oral Toxicity@ and Subacute Dermal Toxicity. Materials@ methods@ and results of individual tests are presented in this report. The test material API #78-4 produced moderately irritating primary skin effects. The acute dermal test resulted in skin irritation but not systemic toxicity. Subacute dermal testing@ however@ produced not only acute dermal corrosion but also obvious treatment-related signs at the 10 ml/kg dosage level; histopathologic examination of tissues confirmed dermal toxicity at all dosage levels. The oral median lethal dose@ i.e.@ oral LD50@ of the test material is 21.2 ml/kg. The test material@ on the other hand@ was essentially negative for primary eye irritation and did not cause skin sensitization.
API PUBL 27-32068-1980 history
1980API PUBL 27-32068-1980 ACUTE TOXICITY TESTS - API #78-4 - #2 HOME HEATING OIL (50% CAT)