This document defines and illustrates the process for determination of uncertainty of turbofan and turbojet engine in-flight thrust and other measured in-flight performance parameters. The reasons for requiring this information, as specified in the E-33 Charter, are: determination of high confidence aircraft drag; problem rectification if performance is low; interpolation of measured thrust and aircraft drag over a range of flight conditions by validation and development of high confidence analytical methods; establishment of a baseline for future engine modifications. This document describes systematic and random measurement uncertainties and methods for propagating the uncertainties to the more complicated parameter, in-flight thrust. Methods for combining the uncertainties to obtain given confidence levels are also addressed. Although the primary focus of the document is in-flight thrust, the statistical methods described are applicable to any measurement process.