ASTM D6561-20
Standard Test Method for Determination of Aerosol Monomeric and Oligomeric Hexamethylene Diisocyanate (HDl) in Air with (Methoxy-2–phenyl-1) Piperazine (MOPIP) in the Workplace

Standard No.

ASTM D6561-20

Release Date

2020

Published By

American Society for Testing and Materials (ASTM)

Latest

ASTM D6561-20

Scope

1.1 This test method covers the determination of aerosol hexamethylene diisocyanate (HDI) in air samples collected from workplace and ambient atmospheres. The method described in this test method collects separate fractions. One fraction will be dominated by vapor, and the other fraction will be dominated by aerosol. The results obtained from the analysis of the separate fractions do not necessarily represent the true partition of the measured HDI physical phases, and should only be considered a representation of the general trend in the physical phase partition within samples. The analyses of the two fractions are different, and are provided in separate, linked, standards to avoid confusion. This test method is principally used to determine short term exposure (15 min) of HDI in workplace environments for personal monitoring or in ambient air. The analysis of the vapor fraction is performed separately, as described in Test Method D6562. 1.2 Differential air sampling is performed with a segregating device. The aerosol fraction is collected on a polytetrafluoroethylene (PTFE) filter. 1.3 The analysis of the aerosol fraction is performed by using a high performance liquid chromatograph (HPLC) equipped with an ultraviolet (UV) detector. An ultra high performance liquid chromatograph (UPLC) can also be used, provided that its performance is equivalent to what is stated in this standard. The range of application of the test method has been validated from 0.052 to 1.04 µg of monomeric HDI/mL, which corresponds, based on a 15 L air sample, to concentrations from 0.004 to 0.070 mg/m3 of HDI. Those concentrations correspond to a range of aerosol phase concentrations from 0.5 ppb (V) to 10 ppb (V) and cover the established threshold limit valve (TLV) value of 5 ppb (V). 1.4 The quantification limit for the monomeric HDI is 0.041 µg per mL, which corresponds to 0.003 mg/m3 for a 15 L sampled air volume. This value is equivalent to ten times the standard deviation obtained from ten measurements carried out on a standard solution in contact with the PTFE filter whose concentration of 0.1 µg/mL is close to the expected detection limit. 1.5 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard. 1.6 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use. See Section 9 for additional hazards. 1.7 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.

ASTM D6561-20 Referenced Document

• ASTM D1193 Standard Specification for Reagent Water
• ASTM D1356 Standard Terminology Relating to Sampling and Analysis of Atmospheres*， 2024-04-22 Update
• ASTM D1357 Standard Practice for Planning the Sampling of the Ambient Atmosphere
• ASTM D4840 Standard Guide for Sample Chain-of-Custody Procedures
• ASTM D5337 Standard Practice for Flow Rate for Calibration of Personal Sampling Pumps
• ASTM D6562 Standard Test Method for Determination of Gaseous Hexamethylene Diisocyanate (HDI) in Air with 9-(N-methylaminomethyl) Anthracene Method (MAMA) in the Workplace

ASTM D6561-20 history

• 2020 ASTM D6561-20 Standard Test Method for Determination of Aerosol Monomeric and Oligomeric Hexamethylene Diisocyanate (HDl) in Air with (Methoxy-2–phenyl-1) Piperazine (MOPIP) in the Workplace
• 2006 ASTM D6561-06(2016) Standard Test Method for Determination of Aerosol Monomeric and Oligomeric Hexamethylene Diisocyanate (HDl) in Air with (Methoxy-2&x2013;phenyl-1) Piperazine (MOPIP) in the Workplace
• 2006 ASTM D6561-06(2011) Standard Test Method for Determination of Aerosol Monomeric and Oligomeric Hexamethylene Diisocyanate (HDl) in Air with (Methoxy-2x2013;phenyl-1) Piperazine (MOPIP) in the Workplace
• 2006 ASTM D6561-06 Standard Test Method for Determination of Aerosol Monomeric and Oligomeric Hexamethylene Diisocyanate (HDl) in Air with (Methoxy-2-phenyl-1) Piperazine (MOPIP) in the Workplace
• 2000 ASTM D6561-00 Standard Test Method for Determination of Aerosol Monomeric and Oligomeric Hexamethylene Diisocyanate (HDl) in Air with (Methoxy-2-phenyl-1) Piperazine (MOPIP) in the Workplace