General Administration of Quality Supervision, Inspection and Quarantine of the People‘s Republic of China
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GB/T 42470-2023
Introduction
The GB/T 42470-2023 standard "Nanotechnology - Toxicity Evaluation of Nanomaterials Based on Zebrafish Embryos" provides guidelines for assessing the toxicity of nanomaterials using zebrafish embryos as a model organism. Zebrafish embryos have become a widely used model for toxicity evaluation due to their genetic similarity to humans and their high sensitivity to environmental changes. This standard outlines the experimental procedures and criteria for evaluating the toxicity of nanomaterials, including exposure methods, observation parameters, and data analysis methods. It aims to provide a systematic and standardized approach for assessing the potential risks of nanomaterials to ensure their safe and responsible use in various applications. By using zebrafish embryos as a testing platform, this standard offers a cost-effective and efficient method for preliminary toxicity screening of nanomaterials before further testing in mammalian models. Additionally, the standard provides valuable insights into the mechanisms of nanomaterial toxicity and contributes to the development of safe and sustainable nanotechnology.
GB/T 42470-2023 history
2023GB/T 42470-2023 Nanotechnology-based Toxicity Evaluation of Nanomaterials in Zebrafish Embryos