OBJECTIVE: The mouse lymphoma forward mutation assay evaluates a test article's mutagenic potential in a specific locus mutation assay using mammalian cells. The objective of the assay is to determine the ability of a test article to induce forward mutations at the thymidine kinase (TK) locus as assayed by colony growth of L5178Y TK-/- mouse lymphoma cells in the presence of 5-trifluorothymidine (TFT).
API PUBL 34-30632-1987 history
1987API PUBL 34-30632-1987 MUTAGENICITY OF API 84-02 HEAVY THERMAL CRACKED NAPHTHA (CAS 64741-83-9) IN A MOUSE LYMPHOMA MUTATION ASSAY- Final Report