INTRODUCTION An inhalation bioassay study with unleaded gasoline was conducted at the International Research and Development Corporation for the American Petroleum Institute (API). The purpose of the study was to evaluate the chronic inhalation toxicity and potential oncogenicity of a reference motor fuel (unleaded gasoline) when administered to rats and mice as a vapor via whole body exposure for approximately 2 years. Gasoline is primarily a mixture of hydrocarbons including aliphatic hydrocarbons@ branched and unsaturated hydrocarbons as well as aromatic compounds (8). In spite of the widespread use of gasoline and vapor exposure encountered under various conditions toxic effects do not normally occur (8). Toxicity to inhaled gasoline vapors has been reported but is generally related to the benzene content of the motor fuel (8). Irritant properties of gasoline have been reported (26) but chronic systemic effects have never been studied. This paper describes in detail the renal pathology and selected clinical data and clinical pathology of Fischer 344 rats and B6C3F1 mice exposed to unleaded gasoline via whole body inhalation exposure.
API PUBL 30-32845-1983 history
1983API PUBL 30-32845-1983 KIDNEY EFFECTS OF UNLEADED GASOLINE - COMPREHENSIVE AND CRITICAL SUMMARY OF OBSERVATIONS IN RATS AND MICE