Microcrystals have the ability to reversibly reduce the tightness of the stratum corneum, increase the transdermal permeability of substances, and improve the absorption efficiency of substances within the skin. Its material properties depend on its special micron-level structure, so soluble microcrystals are defined in the document. The microstructure requirements of the crystal paste specifically include the shape of the crystallite, the height range of the crystallite, and the density of the crystallite array. Among them, the height of microcrystals is directly related to the depth of action of soluble microcrystals on the skin. Therefore, the compilation team conducted in vitro skin staining experiments and in vivo transdermal water loss experiments, and concluded that the experimental results limited the microcrystals in their microstructure. height range, this part of the argument is described in detail in the preparation instructions. It is worth noting that in addition to the height of the microcrystals, the overall moisture content of the microcrystalline patch and the flexibility of its molding material are also related to the depth of action of the microcrystalline patch. Since different manufacturers have different production processes and involve trade secrets, it is difficult to Strictly limited, so the crystallite height range in the document is only for reference.