The safety requirements applicable to fuel cycle facilities (i.e. facilities for uranium ore processing and refining@ conversion@ enrichment@ fabrication of fuel including MOX fuel@ storage and reprocessing of spent fuel@ associated conditioning and storage of waste@ and for related research and development) are established in Ref. [1]. The requirements applicable specifically to MOX fuel fabrication facilities are established in Appendix II of Ref. [1]. This Safety Guide provides recommendations on meeting the requirements established in Sections 5?C10 and in Appendix II of Ref. [1].